Scientific Papers

1. West, M.D., Pereira-Smith, O.M., and Smith, J.R. 1989. Replicative Senescence of Human Skin Fibroblasts Correlates with a Loss of Regulation and Overexpression of Collagenase Activity. Experimental Cell Research, 184:138-147.

2. Shay, J.W., West, M.D., Wright, W.E. 1992. Re-expression of Senescent Markers in De-induced Reversibly Immortalized Cells. Exp. Gerontol. 27: 477-492.

3. West, M.D. 1994. The Cellular and Molecular Biology of Skin Aging. Arch. Dermatol. 130: 87-95.

4. Harley, C.B., Kim, N.W., Prowse, K.R., Weinrich, S.L., Hirsch, K.S., West, M.D., Bacchetti, S., Hirte, H.W., Counter, C.M., Greider, C.W., Piatyszek, M.A., Wright, W.E., and Shay, J.W. 1994. Telomerase, Cell Immortality, and Cancer. Cold Spring Harbor Symposium on Quantitative Biology LIX: 307-315. Cold Spring Harbor Press. Cold Spring Harbor, N.Y.

5. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science, 266: 2011-2014.

6. Feng, J., Funk, W.D., Wang, S-S, Weinrich, S.L., Avilion, A.A., Chiu, C-P., Adams, R., Chang, E., Allsopp, R.C., Siyuan Le, J-Y., West, M.D., Harley, C.B., Andrews, W.H., Greider, C.W., Villeponteau, B.V. 1995. The RNA Component of Human Telomerase. Science. 269: 1236-1241.

7. Linskens, M.H., Harley, C.B., West, M.D., Campisi, J., and Hayflick, L. 1995. Replicative Senescence and Cell Death. Science 267 (5194): 17.

8. West, M.D. 1995. Chromosome and Breakage. In The Encyclopedia of Aging. 2nd Edition. Springer, NY. p179.

9. West, M.D., Shay, J.W., Wright, W.E., and Linskens, M.H.K. 1996. Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence. Exp. Gerontol. 31: 175-193.

10. Effros, R.B., Allsopp, R., Chiu, C-P., Hausner, M.A., Hirji, K., Wang, L., Harley, C.B., Villeponteau, B., West, M.D., and Giorgi, J.V. 1996. Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10: F17-F22.

11. Vaziri, H., West, M.D., Allsopp, R.A., Davison, T.S., Wu, Y-S., Arrowsmith, C.H., Harley, C.B., Poirier, G.G., and Benchiol., S. 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein through poly(ADP-ribose) polymerase. EMBO J. 16: 6018-6033.

12. West, M.D. 1999. Collagenase and Aging. In: The Collagenases, (Ed. Hoeffler, W.) R.G. Landes Co., Austin, TX, p. 241-254.

13. Matsunaga, H., Handa, J.T., Aotaki-Keen, A., Sherwood, S.W., West, M.D., and Hjelmeland, L.M. 1999. Beta-galactosidase Histostochemistry and Telomere Loss in Senescent Retinal Pigment Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 40:197-202.

14. Lanza, R.P., Arrow, K.J., Axelrod, J., Baltimore, D., Benacerraf, B., Bloch, K.E., Bloembergen, N., Brown, H.C., Brown, M.S., Cibelli, J.B., Cohen, S., Cooper, L.N., Corey, E.J., Dulbecco, R., Fischer, E.H., Fitch, V.L., Friedman, J.L., Friedman, M., Furchgott, R.F., Gell-Mann, M., Glaser, D.A., Glashow, S.L., Gilbert, W., Goldstein, J.L., Gould, S.J., Guillemin, R., Hauptman, H.A., Herschbach, D., Hoffman, R., Hood, L., Hubel, D.H., Karle, J., Klein, L.R., Kohn, W., Kornberg, A., Krebs, E.G., Lederman, L.M., Lederberg, J., Lee, D.M., Lucas, R.E., Marcus, R.A., Merrifield, R.B., Miller, M.H., Modigliani, F., Molina, M.J., Mullis, K., Murad, F., Murray, J.E., Nathans, D., Nirenberg, M.W., North, D.C., Olah, G.A., Palade, G.E., Perl, M.J., Ramsey, N.F., Richter, B., Roberts, R.J., Robl, J.M., Samuelson, P.A., Schwartz, M., Sharp, P.A., Smalley, R.E., Smith, H.O., Solow, R.M., Taube, H., Tonegawa, S., Watson, J.D., Weinberg, S., Weller, T.H., West, M.D., Wieschaus, E.F., Wiesel, T.N., Wilson, R.W. 1999. Science Over Politics. Science, 283: 1849-1850.

15. Lanza, R.P., Cibelli, J.B., and West, M.D. 1999. Prospects for the use of nuclear transfer in human transplantation. Nature Biotechnology 17(12): 1171-1174.

16. Lanza, R.P., Cibelli, J.B., and West, M.D. 1999. Human therapeutic cloning. Nature Medicine 5(9): 975-977.

17. Lanza, R.P., Cibelli, J.B., Blackwell, C., Cristofalo, V.J., Francis, M.K., Baerlocher, G.M., Mak, J., Schertzer, M., Chavez, E.E., Sawyer, N., Lansdorp, P.M., and West, M.D. 2000. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288: 665-669.

18. Lanza, R.P., Cibelli, J.B., Diaz, F., Moraes, C.T., Farin, P.W., Farin, C.E., Hammer, C.J., West, M.D., and Damiani, P. 2000. Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer. Cloning 2(2): 79-90.

19. Lanza, R.P., Caplan, A.L., Silver, L.M., Cibelli, J.B., West, M.D., and Green, R.M. 2000. The ethical validity of using nuclear transfer in human transplantation. JAMA 284(24): 3175-3179.

20. Lanza, R.P., Cibelli, J.B., West, M.D., Dorff, E., Tauer, C., and Green, R.M. 2001. The ethical reasons for stem cell research. Science 292(5520): 1299b.

21. Cibelli, J.B., Kiessling, A.A., Cunniff, K., Richards, C., Lanza, R.P., and West, M.D. 2001. Somatic cell nuclear transfer in humans: Pronuclear and early embryonic development, e-biomed: J. Regen. Med. 2: 25-31.

22. Lanza, R.P., Cibelli, J.B., Faber, D., Sweeney, R.W., Henderson, B., Nevala, W., West, M.D., and Wettstein, P.J. 2001. Cloned animals can be healthy and normal. Science 294(5548): 1893-1894.

23. Arrow KJ, Axelrod J, Benacerraf B, Berg P, Bishop JM, Bloembergen N, Brown HC, Cibelli J, Cohen S, Cooper LN, Corey EJ, Cronin JW, Curl R Jr, Dulbecco R, Fischer EH, Fitch VL, Fogel R, Friedman JI, Furchgott RF, Gell-Mann M, Gilbert W, Gilman A, Glaser D, Glashow SL, Green RM, Greengard P, Guillemin R, Hayflick L, Hauptman HA, Heckman JJ, Heeger A, Herschbach D, Hubel DH, Hulse R, Kandel E, Karle J, Klein LR, Kohn W, Kornberg A, Krebs EG, Lanza RP, Laughlin R, Lederman L, Lee DM, Lewis E, Lipscomb W Jr, Marcus RA, McFadden D, Merrifield RB, Merton R, Modigliani F, Molina MJ, Murad F, Nirenberg MW, North DC, Olah GA, Osheroff D, Palade GE, Perl M, Ramsey NF, Richter B, Roberts RJ, Samuelson PA, Schwartz M, Sharp PA, Smalley RE, Smith HO, Solow RM, Stormer H, Taube H, Taylor R, Thomas ED, Tobin J, Tonegawa S, Townes C, Watson JD, Weinberg S, Weller TH, West MD, Wieschaus EF, Wiesel TN, Wilson RW. 2001. Nobel laureates' letter to President Bush. Washington Post. Feb. 22, 2001.

24. Cibelli, J.B., Campbell, K.H., Seidel, G.E., West, M.D., Lanza, R.P. 2002. The health profile of cloned animals. Nature Biotech. 20: 13-14.

25. Lanza, R.P., Cibelli, J.B., and West, M.D. 2002. Transparency in public relations. Nat. Biotechnol. 20: 117-118.

26. Cibelli, J.B., Lanza, R.P., West, M.D., and Ezzell, C. 2002. The first human cloned embryo. Sci. Am. 286: 44-51.

27. Cibelli, J.B., Grant, K.A., Chapman, K.B., Cunniff, K., Worst, T., Green, H.L., Walker, S.J., Gutin, P.H., Vilner, L., Tabar, V., Dominko, T., Kane, J., Wettstein, P.J., Lanza, R.P., Studer, L., Vrana, K.E., and West, M.D. 2002. Parthenogenetic stem cells in nonhuman primates. Science 295: 819.

28. Butler, R.N., Rothman, D., Harman, S.M., Fossel, M., Heward, C.B., Miller, R.A., Olshansky, S.J., Perls, T.T., Rothman, S.M., Warner, H.R., West, M.D., and Wright, W.E. 2002. Is there an anti-aging medicine? J. Gerontol. A. Biol. Sci. 57(9): B333-338. An interdisciplinary workshop of the International Longevity Center – USA. (available at:

29. Lanza, R.P., Chung, H.Y., Yoo, J.J., Wettstein, P.J., Blackwell, C., Borson, N., Hofmeister, E., Schuch, G., S, S., Moraes, C.T., West, M.D., and Atala, A. 2002. Generation of histocompatible tissues using nuclear transplantation. Nature Biotechnology 20(7): 689-696.

30. Vrana, K.E., Hipp, J.D., Goss, A.M., McCool, B.A., Riddle, D.R., Walker, S.J., Wettstein, P.J., Studer, L.P., Tabar, V., Cunniff, K., Chapman, K., Vilner, L., West, M.D., Grant, K.A., and Cibelli, J.B. 2003. Nonhuman primate parthenogenetic stem cells. Proc. Natl. Acad. Sci. USA, 100(suppl. 1): 11911-11916.

31. West, M.D. 2003. Back to Immortality: The Opportunities and Challenges of Therapeutic Cloning. Life Extension 9(11): 63-70.

32. Lanza, R., Chung, Y., West, M.D., and Campbell, K.H. 2003. Comment on “Molecular correlates of primate nuclear transfer failures”. Science, Apr 11;300(5617):297.

33. Lanza, R., Moore, M.A., Wakayama, T., Perry, A.C., Shieh, J-H., Hendrikx, J., Leri, A., Chimenti, S., Monsen, A., Nurzynska, D., West, M.D., Kajstura, J., and Anversa, P. 2004. Regeneration of infarcted heart with stem cells derived by nuclear transplantation. Circ. Res. 94(6): 820-827.

34. Butler, R.N., Warner, H.R., Williams, T.F., Austad, S.N., Brody, J.A., Campisi, J., Cerami, A., Cohen, G., Cristofalo, V.J., Drachman, D.A., Finch, C.E., Fridovich, I., Harley, C.B., Havlik, R.J., Martin, G.M., Miller, R.A., Olshansky, S.J., Pereira-Smith, O.M., Smith, J.R., Sprott, R.L., West, M.D., Wilmoth, J.R., and Wright, W.E. 1994. The aging factor in health and disease: the promise of basic research on aging. Aging Clin. Exp. Res. 16(2): 104-11; discussion 111-2.

35. Klimanskaya, I., Hipp, J., Rezai, K.A., West, M., Atala, A., Lanza, R. 2004. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning and Stem Cells, 6(3): 217-245.

36. West, M. (2004). "An interview with Michael West. Interviewed by Vicki Glaser." Rejuvenation Res 7(1): 65-70

37. Klimanskaya, I., Chung, Y., Meisner, L., Johnson, J., West, M.D., and Lanza, R. 2005. Human Embryonic Stem Cells Derived Without Feeder Cells. Lancet 365(9467): 4997.

38. Lanza, R., Shieh, J-H., Wettstein, P.J., Sweeney, R.W., Wu, K., Weisz, A., Borson, N., Henderson, B., West, M.D., and Moore, M.A.S. 2005. Long-Term Bovine Hematopoietic Engraftment with Clone-derived Stem Cells. Cloning and Stem Cells, 7(2): 95-106.

39. Wilmut, I., West, M.D., Lanza, R., Gearhart, J.D., Smith, A., Colman, A., Trounson, A., and Campbell, K.H. 2005. Human Embryonic Stem Cells. Science Online December 13.

40. West, M.D. 2007. Mortal and Immortal Cells: Gerontology in the Age of Regenerative Medicine. In: Physiological Basis of Aging and Geriatrics, 4th Edition, Informa Healthcare (Ed. P. Timiras).

41. West, M .D. and Mason, C. 2007. Mapping the human embryome: 1 to 10e13 and all the cells in between. Reg. Med. Jul;2(4):329-33.

42. West, M.D., Sargent, R.G., Long, J., Brown, C., Chu, J-S., Kessler, S., Derugin, N., Sampathkumar, J., Burrows, C., Vaziri, H., Williams, R., Chapman, K.B., Larocca, D., Loring, J.F., and Murai, J. 2008. The ACTCellerate Initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives. Reg. Med. 3(3): 287-308.

43. West, M.D. Embryonic Stem Cells: Prospects of Regenerative Medicine for the Treatment of Human Aging. In: The Future of Aging, (Eds. Fahy, G.M., West, M.D., Coles, L.S., and Harris, S.B.) Springer, Berlin, Germany (In Press).

44. Vaziri H, Chapman K, Guigova A, Teichroeb J, Lacher M, Sternberg H, Singec I, Briggs L, Wheeler J, Sampathkumar J, Gonzalez R, Larocca D, Murai J, Snyder E, Andrews W, Funk W, West M.D. 2010. Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming. Regen. Med. March 16 [Epub ahead of print].

45. West, M.D. and Vaziri, H. 2010. Back to Immortality: The restoration of embryonic telomere length during induced pluripotency. Regen. Med. 5(4):485-488.

46. Funk, Walter D., Labat, Ivan, Sampathkumar, Janani, Gourraud, Pierre-Antoine, Oxenberg, Jorge R., Rosler, Elen, Steiger, Daniel, Sheibani, Nadia, Caillier, Stacy, Stache-Crain, Birgit, Johnson, Julie A., Meisner, Lorraine, Lacher, Markus D., Chapman, Karen B., Park, Myung Jin, Shin, Kyoung-Jin, Dr- manac, Rade, West, Michael D., Evaluating the Genomic and Sequence Integrity of human ES cell lines; Comparison to Normal Genomes, Stem Cell Research (2011), doi: 10.1016/j.scr.2011.10.001

47. Sternberg, H. Murai, J.T., Erickson, I.E., Funk, W.D., Das, S., Wang, Q., Snyder, E., Chapman, K.B., Vangsness, C.T. Jr., and West, M.D. 2012. A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme. Regen. Med. 7(4): 481-501.

48. Prestwich, G.D., Erickson, I., Zarembinski, T.I., West, M., and Tew W.P. 2012. The translational imperative: Making cell therapy simple and effective. Acta Biomater. July 7 [Epub ahead of print].

49. Chapman, K.B., Predes, M.J., Sternberg, H., Kidd, J.L., Funk, W.D., Wagner, J., and West, M.D. 2012. Col10A1 expression is elevated in diverse solid tumor types and is associated with tumor vasculature. Future Oncology 8(8): 1031-1040.

50. Sternberg, H., Kidd, J., Murai, J.T., Jiang, J., Rinon, A., Erickson, I.E., Funk, W.D., Wang, Q., Chapman, K.B., Vangsness, Jr. C.T., and West, M.D. 2012. Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates. Regen Med. 2012 Dec 18. [Epub ahead of print].

51. Bignone, P.A., Krupa, R.A., Sternberg, H., Funk, W.D., Snyder, E.Y., West, M.D., and Larocca, D. 2013. Identification of Human Embryonic Progenitor Cell Targeting Peptides Using Phage Display. PLoS ONE 8(3): e58200.

52. Sternberg, H., Janus, J., and West, M. 2013. Defining cell-matrix combination products in the era of pluripotency. Biomatter 2013 Jan 1;3(1). pii: e24496.

53. Tsviya Olender, T. Safran, M., Edgar, R., Stelzer, G., Nativ, N., Rosen, N., Shtrichman, R., Mazor, Y., West, M.D., Keydar, I., Rappaport, N., Belinsky, F., Warshawsky, D., and Lancet, D. 2013. An Overview of Synergistic Data Tools for Biological Scrutiny. Israel J. Chem., 53: 185–198.

54. Edgar, R., Mazor, Y., Rinon, A., Blumenthal, J., Golan, Y., Buzhor, E., Livnat, I., Ben-Ari, S., Lieder, I., Shitrit, A., Gilboa, Y., Ben-Yehudah, A., Edri, O., Shraga, N., Bogoch, Y., Leshansky, L., Aharoni, S., West, M.D., Warshawsky, D., and Shtrichman, R. 2013. LifeMap Discovery: The embryonic development, stem cells, and regenerative medicine research portal. PLoS ONE 8(7): epublished ahead of print.

55. Chapman, K.B., Prendes, M.J., Kidd, J.L., Sternberg, H., West, M.D., and Wagner, J. 2013. Elevated expression of cancer/testis antigen FSIP1 in ER-positive breast tumors Biomark Med. 7(4): 601-11.

56. Sternberg, H., Jiang, J., Sim, P., Kidd, J., Janus, J., Rinon, A., Edgar, R., Shitrit, A., Larocca, D., Chapman, K.B., Binette, F., and West, M.D. 2014. Human embryonic stem cell-derived neural crest cells capable of expressing markers of osteochondral or meningeal-choroid plexus differentiation. Regen. Med. 9(1): 53-66.

57. Caplan, A.I. and West, M.D. 2014. Progressive Approval: A Proposal for a New Regulatory Pathway for Regenerative Medicine. Stem Cells Transl. Med. 3(5) 560-563.

58. Yu, J., Adisetiyo, H., Little, G.H., Vangsness, C.T. Jr., Jiang, J., Sternberg, H., West, M.D., and Frenkel, B. 2014. Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line. J. Cell Physiol. 230(2): 237-41.

59. Bignone PA, Krupa RA, West MD, Larocca D. 2014. Selection of Phage Display Peptides Targeting Human Pluripotent Stem Cell-Derived Progenitor Cell Lines. Methods Mol Biol. 1357:269-83.

60. Singh, R.K., Mallela, R.K., Cornuet, P.K., Reifler, A.N., Chervenak, A.P., West, M.D., Wong, K.Y., and Nasonkin, I.O. 2015. Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures. Stem Cells Dev. 24(23): 2778-95.

61. West, M.D. Binette, F., Larocca, D., Chapman, K.B., Irving, C., and Sternberg, H. 2016. The Germline/Soma Dichotomy: Implications for Aging and Degenerative Disease. Regen. Med. 11(3): 331-334.